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Are ultra-processed foods a public health hazard?

Are ultra-processed foods a public health hazard? I'll gather the latest evidence on their health risks.

Yes, according to current evidence, high consumption of ultra-processed foods (UPFs) is considered a public health hazard by many researchers and public health bodies, though the picture is nuanced.

What are ultra-processed foods?

There is no universally accepted regulatory definition, but most research uses the NOVA Food Classification System. NOVA was a milestone published in 2009 that categorises foods by type, intensity and purpose of processing.

Ultra-Processed Foods (UPF; NOVA "Group 4") refers to "industrial formulations made entirely or mostly from substances extracted from foods (oils, fats, sugar, starch, and proteins), derived from food constituents (hydrogenated fats and modified starch), or synthesized in laboratories from food substrates"

Other definitions describe them as "formulations of ingredients, mostly of exclusive industrial use, that result from a series of industrial processes"

The ultra-processed group includes all foods and drinks made using intense physical or chemical processes or containing cosmetic food additives and other industrial ingredients (eg, artificial flavours, hydrogenated oils, glucose/fructose corn syrup)

These foods are generally convenient, affordable, highly palatable, and often intensively advertised. Examples under NOVA include candies, packaged snacks, sugary drinks, and ready-to-eat meals. They tend to be high in sugar, salt, and unhealthy fats but low in essential nutrients such as fiber and vitamins

Evidence linking UPFs to adverse health outcomes

The strongest synthesis to date is a 2024 umbrella review of epidemiological meta-analyses published in The BMJ:

•The search identified 45 unique pooled analyses, including 13 dose-response associations and 32 non-dose-response associations (n=9 888 373).
•Direct associations were found between exposure to ultra-processed foods and 32 (71%) health parameters spanning mortality, cancer, and mental, respiratory, cardiovascular, gastrointestinal, and metabolic health outcomes.

Using pre-specified evidence classification:

•Convincing evidence (class I) supported direct associations between greater ultra-processed food exposure and higher risks of incident cardiovascular disease related mortality (risk ratio 1.50, 95% confidence interval 1.37 to 1.63; GRADE=very low) and type 2 diabetes (dose-response risk ratio 1.12, 1.11 to 1.13; moderate), as well as higher risks of prevalent anxiety outcomes (odds ratio 1.48, 1.37 to 1.59; low) and combined common mental disorder outcomes (odds ratio 1.53, 1.43 to 1.63; low)
•Highly suggestive (class II) evidence indicated that greater exposure to ultra-processed foods was directly associated with higher risks of incident all cause mortality (risk ratio 1.21, 1.15 to 1.27; low), heart disease related mortality (hazard ratio 1.66, 1.51 to 1.84; low), type 2 diabetes (odds ratio 1.40, 1.23 to 1.59; very low), and depressive outcomes (hazard ratio 1.22, 1.16 to 1.28; low), together with higher risks of prevalent adverse sleep related outcomes (odds ratio 1.41, 1.24 to 1.61; low), wheezing (risk ratio 1.40, 1.27 to 1.55; low), and obesity (odds ratio 1.55, 1.36 to 1.77; low)

A more recent large synthesis published September 2024 in Family Medicine and Community Health pooling 51 prospective cohort studies involving nearly 9 million participants found similar results:

People with the highest UPF consumption had a:

•24% higher risk of cardiovascular events like heart attacks and strokes
•23% higher risk of obesity or overweight
•24% higher risk of metabolic syndrome or diabetes
•27% higher risk of depression and anxiety
•31% higher risk of digestive diseases, including Crohn’s disease
•12% higher risk of cancer
•18% higher risk of death from any cause

Dose-response analysis found for every extra 100 grams (about 3.5 ounces) of UPFs consumed daily, risks increased by:

•14% higher risk of cardiovascular events
•4% higher risk of cancer

There is also experimental evidence: Researchers have also conducted clinical trials showing that people who consume a diet high in ultra-processed foods tend to overeat and gain unwanted weight

Researchers have found links between the consumption of highly processed foods (commonly called ultra-processed foods, or UPFs) and a range of negative health outcomes, including cardiovascular disease, obesity and certain cancers

Plausible mechanisms

Researchers propose several plausible mechanisms:

"Plausible mechanisms for harm include nutrient imbalances, overeating, reduced consumption of health-protective [plant compounds], toxic contaminants from processing or packaging, harmful additives and mixtures of additives, and subsequent inflammation," the researchers wrote, adding that a diet high in UPFs may also disrupt blood sugar and cholesterol levels, gut bacteria, and kidney or liver function

Other highlighted mechanisms:

•Softer, uniform textures facilitate rapid consumption, preventing sufficient chewing to trigger satiety signals
•Highly palatable designs encourage overeating — many contain additives, preservatives, emulsifiers, and artificial sweeteners and softer textures and hyper-palatable designs encourage overeating.
•Displacement of nutrient-dense foods and reduced intake of protective phytochemicals, exposure to harmful additives or contaminants from processing and packaging.

Why public health experts call it a hazard

The umbrella review concluded:

Greater exposure to ultra-processed food was associated with a higher risk of adverse health outcomes, especially cardiometabolic, common mental disorder, and mortality outcomes

These findings provide a rationale to develop and evaluate the effectiveness of using population based and public health measures to target and reduce dietary exposure to ultra-processed foods for improved human health

A BMJ analysis in 2023 argued: Incomplete understanding of the multiple mechanisms underlying the link between ultra-processed foods and cardiometabolic health should not be an excuse for inaction

Policy movement reflects this concern:

•The FDA is working with the U.S. Department of Agriculture (USDA) as part of a joint effort to develop a uniform definition of UPFs and has advanced a proposed definition for federal nutrition policy and research.
•The WHO aims to develop guidelines on the consumption of ultra-processed foods, providing "much-needed, evidence-based global guidance", and said that it would present a profiling model for regulatory measures on ultra-processed foods by the end of 2026 and guidelines on consumption by 2028
•Some have estimated that children get over 60% of their calories from such foods

Researchers have also noted that because many chronic diseases often occur together, reducing UPF intake could be an important step in preventing multiple health problems at once

Important nuances and limitations

1.Quality of evidence is mostly low. In the umbrella review, 22 pooled analyses were rated as low quality, with 19 rated as very low quality and four rated as moderate quality. Most data are observational, so causality cannot be definitively proven, and adjustment for confounders varies.
2.Not all UPFs are equal. Experts increasingly stress heterogeneity:

"While many ultra-processed foods tend to be of poor nutritional quality and should generally be limited or avoided, processing itself is not inherently harmful,"

A much-discussed study found the increased disease risk was mainly driven by sugary soft drinks and processed meats (e.g., sausages). In contrast, the study found no increased risk for plant-based highly processed products

Similarly, foods such as some whole grain breads, breakfast cereals and dairy products were associated with lower colorectal cancer risk, while processed meats were associated with higher risk

A dietitian noted: "[A] sugary soda and a fiber-rich packaged whole grain bread may both meet criteria for ultra-processing, but they're nutritionally very different,"

3.Dose-response matters. There isn't a single cutoff at which UPFs become harmful. What this new research suggests is more of a dose-response relationship; the more ultra-processed food in the diet, the higher the observed risk for several chronic diseases

Bottom line

At the population level, evidence consistently links higher UPF intake — especially sugary drinks, processed meats, packaged snacks, and ready-to-eat meals high in added sugars, salt and unhealthy fats — to higher risks of obesity, type 2 diabetes, cardiovascular disease, depression, digestive diseases, cancer and premature death. This supports calls for public health measures to reduce exposure.

This does not mean every food classified as ultra-processed is equally hazardous. Fortified whole-grain cereals, canned beans, or plain yogurts that are technically ultra-processed under NOVA may still contribute nutrients and are not consistently linked to harm. Public health guidance focuses on reducing overall dietary pattern reliance on hyper-palatable, nutrient-poor UPFs and prioritizing whole or minimally processed foods most of the time, cooking at home, limiting sugary drinks and processed meats, and checking labels for added sugars, sodium and saturated fat.

Citations (3)

  1. 1bmj.comAcademic
    Ultra-processed foods and cardiometabolic health: public health policies to reduce consumption cannot wait

    Backs: “There is no universally accepted regulatory definition, but most research uses the NOVA Food Classification System.”

  2. 2healthline.comCommercial contentquality 0.81
    Eating More Ultra-Processed Foods Worsens Health, Raises Death Risk

    Backs: “The ultra-processed group includes all foods and drinks made using intense physical or chemical processes or containing cosmetic food additives and other industrial ingredients (eg, artificial flavours, hydrogenated oils, glucose/fructose corn syrup). These foods are generally convenient, affordable, highly palatable,…”

  3. 3fabresearch.orgNot yet classified
    FAB: Lane M et al 2024 - Ultra-processed food exposure and adverse health outcomes: umbrella review of epidemiological meta-analyses

    Backs: “The strongest synthesis to date is a 2024 umbrella review of epidemiological meta-analyses published in The BMJ: The search identified 45 unique pooled analyses, including 13 dose-response associations and 32 non-dose-response associations (n=9 888 373).”