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Are ultra-processed foods a public health hazard?

Ultra-processed foods and public health — I'll pull the latest evidence on risks and what health agencies are saying.

Yes - major health agencies and large reviews of epidemiological evidence increasingly treat diets high in ultra-processed foods (UPFs) as a public health hazard, although there is nuance about heterogeneity within the category.

What are Ultra-Processed Foods?

The term originates from the NOVA food classification system, which defines foods in four categories ranging from least to most processed .

•Ultra-Processed Foods (UPF; NOVA "Group 4") refers to "industrial formulations made entirely or mostly from substances extracted from foods (oils, fats, sugar, starch, and proteins), derived from food constituents (hydrogenated fats and modified starch), or synthesized in laboratories from ... Source: Food and Agriculture Organization of the United Nations

They encompass a broad range of ready to eat products, including packaged snacks, carbonated soft drinks, instant noodles, and ready-made meals. These products are characterised as industrial formulations primarily composed of chemically modified substances extracted from foods, along with additives to enhance taste, texture, appearance, and durability, with minimal to no inclusion of whole foods.

Other definitions note they have one or more ingredients that wouldn't be found in a kitchen, like chemical-based preservatives, emulsifiers like hydrogenated oils, sweeteners like high fructose corn syrup, and artificial colors and flavors and undergo processing techniques like pre-frying, molding, extrusion, fractioning.

How Widespread Is Exposure?

In the United States the exposure is very high:

•Nearly 75% of the U.S. food supply is estimated to be ultra-processed. More than half of the calories that the average American adult consumes come from UPFs; in children, that number is more than 60%
•Between August 2021 to August 2023, the mean percentage of total calories consumed from ultra-processed foods among those aged one year and older was 55%
•For youth, the percentage was 61.9% and for adults 53% in that period, after a decrease from previous years

Analyses of worldwide ultra-processed food sales data and consumption patterns indicate a shift towards an increasingly ultra-processed global diet. Across high income countries, the share of dietary energy derived from ultra-processed foods ranges from 42% and 58% in Australia and the United States, respectively.

What Does the Evidence Show?

The most comprehensive assessment to date is an umbrella review published in The BMJ on Feb 28, 2024:

•Need more reasons to stop eating ultra-processed food? How about 32 of them? ... findings, published online Feb. 28, 2024, by The BMJ, come from a review of 45 analyses published in the last three years, involving about 10 million people in total
•The search identified 45 unique pooled analyses, including 13 dose-response associations and 32 non-dose-response associations (n=9 888 373). Overall, direct associations were found between exposure to ultra-processed foods and 32 (71%) health parameters spanning mortality, cancer, and mental, respiratory, cardiovascular, gastrointestinal, and metabolic health outcomes
•Consistent evidence shows that higher exposure to ultra-processed foods is associated with an increased risk of 32 damaging health outcomes including cancer, major heart and lung conditions, mental health disorders, and early death

Graded evidence from that review:

•Convincing evidence (class I) supported direct associations between greater ultra-processed food exposure and higher risks of incident cardiovascular disease related mortality (risk ratio 1.50, 95% confidence interval 1.37 to 1.63) and type 2 diabetes (dose-response risk ratio 1.12, 1.11 to 1.13), as well as higher risks of prevalent anxiety outcomes (odds ratio 1.48, 1.37 to 1.59) and combined common mental disorder outcomes (odds ratio 1.53, 1.43 to 1.63)
•Highly suggestive (class II) evidence indicated that greater exposure to ultra-processed foods was directly associated with higher risks of incident all cause mortality (risk ratio 1.21, 1.15 to 1.27), heart disease related mortality (hazard ratio 1.66, 1.51 to 1.84), type 2 diabetes (odds ratio 1.40, 1.23 to 1.59), and depressive outcomes (hazard ratio 1.22, 1.16 to 1.28), together with higher risks of prevalent adverse sleep related outcomes (odds ratio 1.41, 1.24 to 1.61), wheezing (risk ratio 1.40, 1.27 to 1.55), and obesity (odds ratio 1.55, 1.36 to 1.77)

Other syntheses support this:

•Dozens of scientific studies have found links between the consumption of foods often considered ultra-processed with numerous adverse health outcomes, including cardiovascular disease, Type 2 diabetes, cancer, obesity and neurological disorders
•A 2024 umbrella review of 45 meta-analyses including almost 10 million people found that diets high in UPFs are linked to 32 health conditions, including obesity, type 2 diabetes, cardiometabolic diseases, many cancers, gastrointestinal disorders, asthma, anxiety, depression, cardiovascular events, and all-cause mortality

U.S. federal agencies have called the threats clear and convincing: “The threats posed to our health by foods often considered ultra-processed are clear and convincing"

Why Are They Considered Hazardous? Plausible Mechanisms

Researchers point to multiple overlapping features, not just nutrients alone:

•Some characteristics of ultra-processed foods include alterations to food matrices and textures, potential contaminants from packaging material and processing, and the presence of food additives and other industrial ingredients, as well as nutrient poor profiles (for example, higher energy, salt, sugar, and saturated fat, with lower levels of dietary fibre, micronutrients, and vitamins)
•The processes and ingredients used to create UPFs often make these foods hyperpalatable, ... meaning they are designed to be exceptionally appealing to the human palate—and can be addictive
•The disassembling and reassembling of chemical and physical structures caused by processing affects how our bodies metabolize these foods, making them "pre-digested." This leads to rapid absorption of sugar and fat and spikes in blood glucose. It also bypasses the need for the body to break down food, which can lead to a disrupted gut microbiome because of low fiber content and potential harm from additives like emulsifiers

These may act through known or plausible physiological mechanisms including changes to the gut microbiome and increased inflammation

A Tufts study noted people who ate more ultra-processed foods had worse health outcomes, even after accounting for the overall nutritional quality of the foods, suggesting factors beyond nutrients—such as changes to foods’ cellular structure, loss of beneficial chemical compounds, additives, and chemicals from packaging—may create health risks

Are All Ultra-Processed Foods Equally Hazardous?

No. This is an area of active debate and a key caveat.

•A new scientific advisory from the American Heart Association (AHA) has challenged the idea that all ultra-processed foods are unhealthy
•The binary nature of NOVA's review shows substantial heterogeneity in health outcomes across UPF subtypes, with products like sugar... certain dairy products demonstrate neutral or protective effects
•Healthier UPFs are those that, despite undergoing industrial processing, still offer nutritional benefits, such as fiber, protein, vitamins, and minerals, and have limited amounts of added sugars, unhealthy fats, and sodium
•Some examples of healthier ultra-processed foods include: whole grain breads, high-fiber breakfast cereals, certain dairy products, fortified plant-based milks
•As Johns Hopkins notes: Not all ultra-processed foods are equally concerning for health. Many ultra-processed foods are junk foods, but many others are products that we use all the time ... Prepackaged whole grain breads, many yogurts, instant oatmeal, and jarred pasta sauces are all ultra-processed foods, but have lower levels of saturated fats and added sugars while still containing a plethora of nutrients
•Experts note: "It's a balancing act. It's important to identify foods that are of most concern for health … I would like to see the Dietary Guidelines for Americans strike that balance in clear recommendations while not treating all ultra-processed foods with the same broad brush."

The most harmful sub-categories consistently identified are sugary drinks and processed meats, and salty snacks, refined snack foods, instant noodles, candy, and sugar-sweetened beverages.

Limitations and Public Health Interpretation

The BMJ authors and others emphasize limitations:

•Overall, using the GRADE framework, 22 pooled analyses were rated as low quality, with 19 rated as very low quality and four rated as moderate quality
•All included studies were observational, so causation cannot be proven, and adjustment for confounders varies.

Despite low-to-moderate certainty for many individual outcomes, the consistency, dose-response relationships, and breadth of associated conditions have led authors to conclude:

•Greater exposure to ultra-processed food was associated with a higher risk of adverse health outcomes, especially cardiometabolic, common mental disorder, and mortality outcomes. These findings provide a rationale to develop and evaluate the effectiveness of using population based and public health measures to target and reduce dietary exposure to ultra-processed foods
•Existing evidence is sufficiently strong to warrant immediate public health actions to help citizens identify ultra-processed foods and limit their exposure

Proposed public health actions discussed include front-of-package labels, soda taxes, reformulation incentives, school meal standards, and improving affordability and access to minimally processed foods, as UPFs remain shelf stable, convenient, and cheaper per calorie.

Bottom line: Diets high in ultra-processed foods, particularly those high in sugary drinks, processed meats, and calorie-dense salty/sweet snacks, are consistently linked in large population studies to higher risks of cardiometabolic disease, mental health disorders, and early death, and are widely considered a public health hazard. The degree of risk depends on which UPFs, how much is consumed, and what they replace in the diet; some fortified, fiber-rich or protein-rich UPFs can fit into a healthy pattern, but the overall pattern of high UPF consumption — which now provides over half of calories in the U.S. — is considered detrimental to population health.

Citations (4)

  1. 1bmj.comAcademic
    Ultra-processed food exposure and adverse health outcomes: umbrella review of epidemiological meta-analyses

    Backs: “Ultra-Processed Foods (UPF; NOVA "Group 4") refers to "industrial formulations made entirely or mostly from substances extracted from foods (oils, fats, sugar, starch, and proteins), derived from food constituents (hydrogenated fats and modified starch), or synthesized in laboratories from ... Source: Food and…”

  2. 2jhu.eduAcademic
    What Are Ultra-Processed Foods? | Johns Hopkins | Bloomberg School of Public Health

    Backs: “These products are characterised as industrial formulations primarily composed of chemically modified substances extracted from foods, along with additives to enhance taste, texture, appearance, and durability, with minimal to no inclusion of whole foods. Other definitions note they have one or more ingredients that…”

  3. 3harvard.eduAcademic
    More evidence that ultra-processed foods harm health - Harvard Health

    Backs: “The most comprehensive assessment to date is an umbrella review published in The BMJ on Feb 28, 2024: Need more reasons to stop eating ultra-processed food? How about 32 of them? ... findings, published online Feb. 28, 2024, by The BMJ, come from a review of 45 analyses published in the last three years, involving…”

  4. 4healthline.comCommercial contentquality 0.81
    Not All Ultra-Processed Foods Are 'Bad,' Experts Say. Here's Why

    Backs: “health risks. Are All Ultra-Processed Foods Equally Hazardous? No. This is an area of active debate and a key caveat. A new scientific advisory from the American Heart Association (AHA) has challenged the idea that all ultra-processed foods are unhealthy”